SMG1P3
Description
The SMG1P3 (SMG1 pseudogene 3) is a pseudo gene located on chromosome 16.
SMG1P3, also known as UPF1, is a protein kinase involved in nonsense-mediated mRNA decay (NMD). This process degrades mRNAs containing premature termination codons (PTCs), preventing the production of truncated proteins. SMG1P3 acts by phosphorylating other NMD components, ultimately leading to the recruitment of the exosome for mRNA degradation.
SMG1P3, also known as UPF1, is a key component of the nonsense-mediated mRNA decay (NMD) pathway. This pathway is responsible for degrading mRNAs that contain premature termination codons (PTCs). SMG1P3 acts as a protein kinase, phosphorylating other proteins involved in NMD, such as UPF2 and UPF3. This phosphorylation triggers the recruitment of the exosome, a complex of enzymes that degrades the mRNA. SMG1P3 also plays a role in regulating translation and mRNA splicing. By degrading aberrant mRNAs, SMG1P3 ensures the production of functional proteins and maintains the integrity of the transcriptome.
SMG1P3 is also known as -.
