SLX1A
Description
The SLX1A (SLX1 homolog A, structure-specific endonuclease subunit) is a protein-coding gene located on chromosome 16.
SLX1A, also known as GIY-YIG domain-containing protein 1, is the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease. It resolves DNA secondary structures formed during DNA repair and recombination. SLX1A exhibits endonuclease activity towards branched DNA substrates, making single-strand cuts in duplex DNA near junctions with single-stranded DNA. It shows a preference for 5'-flap structures and facilitates symmetrical cleavage of both static and migrating Holliday junctions. SLX1A resolves Holliday junctions by producing two sets of ligatable, nicked duplex products.
SLX1A is also known as GIYD1.
Associated Diseases
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
- FRAXF syndrome
- pentosuria
- myopathy due to calsequestrin and SERCA1 protein overload
- metabolic myopathy due to lactate transporter defect
- Fanconi anemia
- cancer
- urinary bladder carcinoma
