SLU7
Description
The SLU7 (SLU7 homolog, splicing factor) is a protein-coding gene located on chromosome 5.
SLU7 is a protein involved in pre-mRNA splicing, a process that removes introns and joins exons to form mature mRNA. SLU7 plays a crucial role in the second step of splicing, ensuring proper exon joining and intron removal. It is a component of the spliceosome, a complex of proteins and RNA molecules that carry out splicing. SLU7's function involves interactions with other splicing factors and nucleic acids, facilitated by its zinc knuckle motif.
SLU7 is essential for pre-mRNA splicing, acting as a component of the spliceosome. It plays a crucial role in the second catalytic step of splicing, where the free hydroxyl group of exon 1 attacks the 3'-splice site to produce spliced mRNA and the excised lariat intron. SLU7 is required for correctly positioning exon 1 within the spliceosome and for accurately identifying the AG dinucleotide when multiple potential AG sites are present in the 3'-splice site region. It may also contribute to the activation of proximal AG sites and is likely involved in regulating alternative splicing. SLU7 associates with the spliceosome prior to 3'-splice site recognition during step II, potentially during the catalytic process of step I.
SLU7 is also known as 9G8, hSlu7.
Associated Diseases
- asthma
- systemic lupus erythematosus
- allergic disease
- transient myeloproliferative syndrome
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9
- reticular dysgenesis
- cancer
- Fabry disease
