SLIT1
Description
The SLIT1 (slit guidance ligand 1) is a protein-coding gene located on chromosome 10.
Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.
Slit1 acts as a molecular guidance cue during cellular migration. This function is likely mediated through interaction with roundabout homolog receptors. During neural development, Slit1 plays a role in axonal navigation at the ventral midline of the neural tube and the projection of axons to different regions. Along with Slit2, Slit1 is crucial for midline guidance in the forebrain, acting as a repulsive signal to prevent axons projecting from the olfactory bulb from crossing the midline.
SLIT1 is also known as MEGF4, SLIL1, SLIT-1, SLIT3.
