SLCO1A2
Description
The SLCO1A2 (solute carrier organic anion transporter family member 1A2) is a protein-coding gene located on chromosome 12.
The SLCO1A2 gene encodes a protein that is a sodium-independent transporter. This protein is found in the liver and is responsible for the uptake of organic ions, including bile acids, bromosulphophthalein, and some steroidal compounds. The SLCO1A2 gene is a member of the SLC21A family of solute carriers. Alternative splicing of this gene leads to the creation of three transcript variants that encode two different isoforms.
The SLCO1A2 gene encodes a protein that acts as a sodium-independent transporter. This transporter is responsible for the uptake of various organic anions, including bile salts (cholate, deoxycholate, taurocholate, and glycocholate), steroids (dehydroepiandrosterone 3-sulfate, estrone 3-sulfate, and 17beta-estradiol 17-O-(beta-D-glucuronate)), and retinol. It also plays a role in the absorption of bile acids in the intestines, the transport of thyroid hormones (T3 and T4), and the uptake of certain drugs. The transporter's activity is pH-sensitive, with greater activity in acidic environments. It may also contribute to the transport of organic compounds in the testes and the transport of organic anions and signal mediators across the blood-brain barrier.
SLCO1A2 is also known as OATP, OATP-A, OATP1A2, SLC21A3.
Associated Diseases
- progressive supranuclear palsy
- Okt4 epitope deficiency
- cancer
- pentosuria
- tyrosinemia type III
- Dent disease
- neutropenia, severe congenital, 2, autosomal dominant
- COVID-19
