SLC4A9
Description
The SLC4A9 (solute carrier family 4 member 9) is a protein-coding gene located on chromosome 5.
SLC4A9 is an electroneutral chloride/bicarbonate antiporter, which facilitates the movement of chloride ions into the cell and bicarbonate ions out of the cell. This process is coupled with the movement of sodium ions, and it is primarily active across the basolateral membrane. SLC4A9 is thought to play a role in salivary secretion. This protein can also exchange chloride and bicarbonate ions in the presence of potassium, cesium, lithium, and rubidium. However, SLC4A9 does not appear to contribute to chloride/bicarbonate exchange in the apical membrane of the upper villous epithelium.
SLC4A9 is also known as AE4.
Associated Diseases
- familial idiopathic steroid-resistant nephrotic syndrome
- nephronophthisis
- nephrotic syndrome, IIa 26
- congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization
- multicystic dysplastic kidney
- focal segmental glomerulosclerosis 9
- primary hyperoxaluria type 2
- familial juvenile hyperuricemic nephropathy type 1
- lipoprotein glomerulopathy
- nephrotic syndrome 16
- focal segmental glomerulosclerosis 7
- sporadic idiopathic steroid-resistant nephrotic syndrome
- nephrotic syndrome, type 4
- glomerulopathy with fibronectin deposits 2
- proteinuria, chronic benign
- nail-patella-like renal disease
- C3 glomerulonephritis
