SLC47A2

Description

The SLC47A2 (solute carrier family 47 member 2) is a protein-coding gene located on chromosome 17.

SLC47A2 is a gene that encodes a protein involved in the excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This protein belongs to a family of transporters that share homology with bacterial MATE (multi antimicrobial extrusion protein or multidrug and toxic compound extrusion) proteins responsible for drug resistance. SLC47A2 is one of two members of the MATE transporter family located on chromosome 17. Different isoforms of this protein are encoded by alternatively spliced transcript variants. The bacterial homologue of SLC47A2, NorM, was identified in 1998. NorM, a drug/sodium antiporter, is the first example of a Na+-coupled multidrug efflux transporter discovered. It is the prototype of a new transporter family called the multidrug and toxic compound extrusion family. The X-ray structure of NorM reveals an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices.

SLC47A2, also known as MATE-2 or hMATE-2, is a multidrug efflux pump that functions as a H(+)/organic cation antiporter. It transports a variety of cationic compounds out of cells, including model cations like tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), platinum-based drugs like oxaliplatin, weak bases that are positively charged at physiological pH like cimetidine, other platinum-based drugs like cisplatin, and the antidiabetic drug metformin. It also transports endogenous compounds such as creatinine, thiamine, and estrone-3-sulfate. SLC47A2 plays a crucial role in the excretion of drugs, toxins, and endogenous metabolites through the kidney.

SLC47A2 is also known as MATE2, MATE2-B, MATE2-K, MATE2K.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing