SLC43A2
Description
The SLC43A2 (solute carrier family 43 member 2) is a protein-coding gene located on chromosome 17.
SLC43A2 acts as a uniporter, facilitating the movement of specific amino acids like L-phenylalanine, L-methionine, and L-branched-chain amino acids across cell membranes. This transport occurs between the extracellular space and the cytoplasm, potentially regulating the reabsorption of neutral amino acids in the kidney and small intestine. The transport process relies on facilitated diffusion and is independent of sodium ions, chloride ions, and pH.
SLC43A2 is also known as LAT4.
Associated Diseases
- mitochondrial DNA depletion syndrome 15 (hepatocerebral type)
- neonatal intrahepatic cholestasis due to citrin deficiency
- combined oxidative phosphorylation deficiency 34
- cancer
