SLC38A10
Description
The SLC38A10 (solute carrier family 38 member 10) is a protein-coding gene located on chromosome 17.
SLC38A10, also known as solute carrier family 38 member 10, is a protein encoded by the SLC38A10 gene in humans. Studies using Immunocytochemistry and GFP SLC38A10 vector on various cell lines and primary cortex neuronal cells have shown that SLC38A10 is localized on the Golgi apparatus and ER organelles. Research on SLC38A10 knockout models suggests a possible association with p53 protein and cell survival. A member of the SLC38A family has been observed to be progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. This suggests that SLC38A may be linked to tumorigenesis and could serve as a potential prognostic marker for the progression of uterine cervical preneoplastic lesions.
SLC38A10 facilitates the bidirectional transport of amino acids. It may act as a glutamate sensor, regulating the glutamate-glutamine cycle and mTOR signaling in the brain. The precise transport mechanism is still under investigation.
SLC38A10 is also known as PP1744, SNAT10.
Associated Diseases
- retinitis pigmentosa and erythrocytic microcytosis
- aceruloplasminemia
- autosomal dominant Kenny-Caffey syndrome
- neonatal intrahepatic cholestasis due to citrin deficiency
- progressive familial intrahepatic cholestasis
- fibular hemimelia
- multiple epiphyseal dysplasia type 1
- hemoglobin D disease
- hemoglobin E-beta-thalassemia syndrome
- osteogenesis imperfecta, IIA 22
- dehydrated hereditary stomatocytosis
