SLC35B1
Description
The SLC35B1 (solute carrier family 35 member B1) is a protein-coding gene located on chromosome 17.
SLC35B1 is an ATP:ADP antiporter that facilitates the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. It imports ATP from the cytosol into the ER lumen and exports ADP in the opposite direction. This activity regulates ER energy metabolism and protein biogenesis. SLC35B1 is part of a calcium-dependent ER to cytosol low energy response axis. When calcium effluxes from the ER to the cytosol, SLC35B1 triggers ATP import into the ER lumen to maintain sufficient ATP supply. It provides ATP to the ER chaperone HSPA5, which drives protein folding and trafficking in the ER. While SLC35B1 can transport dATP, UTP, or UDP in exchange for ATP, the physiological significance of this process is yet to be determined.
SLC35B1 is also known as AXER, UGTREL1.
