SLC30A2
Description
The SLC30A2 (solute carrier family 30 member 2) is a protein-coding gene located on chromosome 1.
SLC30A2 (Solute carrier family 30 member 2) is a protein that in humans is encoded by the SLC30A2 gene. It is a zinc transporter protein that plays a crucial role in cellular zinc homeostasis. SLC30A2 is an electroneutral proton-coupled antiporter that concentrates zinc ions into various intracellular organelles, including endosomes, zymogen granules, and mitochondria. This transport activity protects cells from the potential cytotoxicity of zinc. SLC30A2 also regulates the zinc concentration of milk, transporting zinc ions into secretory vesicles of mammary cells. In addition, SLC30A2 participates in lysosomal-mediated cell death during early mammary gland involution by concentrating zinc ions into lysosomes.
SLC30A2 (also known as Solute carrier family 30 member 2 or Zinc transporter 2) is an electroneutral proton-coupled antiporter that concentrates zinc ions into various intracellular organelles, including endosomes, zymogen granules, and mitochondria. It plays a crucial role in cellular zinc homeostasis, protecting cells from zinc-induced toxicity. SLC30A2 also regulates the zinc concentration of milk by transporting zinc ions into secretory vesicles of mammary cells. By concentrating zinc ions within lysosomes, SLC30A2 participates in lysosomal-mediated cell death during early mammary gland involution. (PubMed:17065149, PubMed:19496757, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306)
SLC30A2 is also known as PP12488, TNZD, ZNT2, ZnT-2.
