SLC30A1
Description
The SLC30A1 (solute carrier family 30 member 1) is a protein-coding gene located on chromosome 1.
SLC30A1, also known as Zinc transporter 1, is a protein encoded by the SLC30A1 gene in humans. It modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx but also Ca++ influx, protecting cells from excessive cation permeation.
SLC30A1 acts as a zinc ion:proton antiporter, primarily functioning at the plasma membrane to mediate zinc efflux from cells. This action helps protect cells from intracellular zinc accumulation and toxicity by pushing zinc out against its electrochemical gradient. Additionally, SLC30A1 can prevent the transport of CACNB2, the regulatory subunit of L-type calcium channels, to the plasma membrane. This modulation of channel expression at the plasma membrane prevents the influx of calcium and zinc into cells, also blocking heavy metal entry via L-type calcium channels. Notably, SLC30A1 can also facilitate zinc entry into the lumen of cytoplasmic vesicles in certain cell types. In macrophages, SLC30A1 increases zinc ion concentration within cytoplasmic vesicles containing engulfed bacteria, contributing to their inactivation.
SLC30A1 is also known as ZNT1, ZRC1.
Associated Diseases
- cancer
- urinary bladder carcinoma
- female infertility due to oocyte meiotic arrest
- premature ovarian failure 19
- invasive hydatidiform mole
- female infertility due to zona pellucida defect
