SLC22A18
Description
The SLC22A18 (solute carrier family 22 member 18) is a protein-coding gene located on chromosome 11.
Solute carrier family 22 member 18 is a protein encoded by the SLC22A18 gene in humans. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been linked to various cancers and syndromes such as Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and diseases affecting this region, as well as in the transport of chloroquine and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been identified.
This protein may act as a transporter of organic cations, utilizing a proton efflux antiport mechanism. It is also likely involved in the transport of chloroquine and quinidine-related compounds within the kidneys.
SLC22A18 is also known as BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A.
