SLC22A17
Description
The SLC22A17 (solute carrier family 22 member 17) is a protein-coding gene located on chromosome 14.
SLC22A17 is a cell surface receptor that binds to LCN2 (24p3), a protein involved in iron homeostasis and transport. When bound to iron-loaded LCN2 (holo-24p3), SLC22A17 internalizes the complex and releases iron, increasing intracellular iron levels and preventing cell death. Alternatively, when bound to iron-free LCN2 (apo-24p3), SLC22A17 internalizes the complex and facilitates iron chelation through an intracellular siderophore, leading to iron transfer outside the cell, reducing intracellular iron levels and promoting apoptosis.
SLC22A17 is also known as 24p3R, BOCT, BOIT, NGALR, NGALR2, NGALR3, hBOIT.
Associated Diseases
- Gollop-Wolfgang complex
- cancer
- tibia, hypoplasia or aplasia of, with polydactyly
- Blount disease
- acheiropody
- Eiken syndrome
- acromesomelic dysplasia 2C, Hunter-Thompson type
- metaphyseal dysplasia, Braun-Tinschert type
- syndactyly type 4
- acromesomelic dysplasia 2A
- Caffey disease
- laurin-Sandrow syndrome
- ghosal hematodiaphyseal dysplasia
- spondyloepimetaphyseal dysplasia, Missouri type
- acromesomelic dysplasia 2B
