SLC15A3
Description
The SLC15A3 (solute carrier family 15 member 3) is a protein-coding gene located on chromosome 11.
SLC15A3 is a proton-coupled amino acid transporter that facilitates the movement of free histidine, dipeptides, and tripeptides across cell membranes. It also plays a role in the innate immune response, likely by transporting bacterial peptidoglycans, such as muramyl dipeptide (MDP), across the endolysosomal membrane. This transport of peptidoglycans is believed to be involved in the activation of toll-like receptors (TLRs) and NOD-like receptors (NLRs), which are key components of the innate immune system. Notably, SLC15A3 has also been shown to transport carnosine, a dipeptide with potential antioxidant and neuroprotective properties.
SLC15A3 is also known as OCTP, PHT2, PTR3, hPHT2.
Associated Diseases
- type 1 diabetes mellitus
- hemoglobin E-beta-thalassemia syndrome
- neutropenia, severe congenital, 2, autosomal dominant
- IRIDA syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- dehydrated hereditary stomatocytosis
- neutropenia-monocytopenia-deafness syndrome
- gluthathione peroxidase deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- microcytic anemia with liver iron overload
- hemoglobin D disease
- Rh deficiency syndrome
- Heinz body anemia
- hemochromatosis type 5
