SLC13A2
Description
The SLC13A2 (solute carrier family 13 member 2) is a protein-coding gene located on chromosome 17.
SLC13A2, also known as Solute carrier family 13 member 2, is a protein encoded by the SLC13A2 gene in humans. This protein is involved in the transport of certain molecules across cell membranes.
SLC13A2, also known as Na(+)/dicarboxylate cotransporter 1, is a low-affinity sodium-dicarboxylate cotransporter that facilitates the entry of citric acid cycle intermediates, including succinate, citrate, fumarate, and alpha-ketoglutarate (2-oxoglutarate), into the small intestine and renal proximal tubule. This transporter moves dicarboxylates into the cell with a likely ratio of 3 Na(+) ions for 1 divalent dicarboxylate, making the process electrogenic. Notably, citrate is transported in its protonated form as a divalent anion, not the trivalent form usually found in blood. SLC13A2 plays a crucial role in renal dicarboxylate transport.
SLC13A2 is also known as NADC1, NaCT, NaDC-1, SDCT1.
Associated Diseases
- cataract
- pentosuria
- uridine-cytidineuria
- isolated sedoheptulokinase deficiency
- familial idiopathic steroid-resistant nephrotic syndrome
- seizures-intellectual disability due to hydroxylysinuria syndrome
- carnosinemia
- iminoglycinuria
- hyperdibasic aminoaciduria type 1
- cystathioninuria
- phosphohydroxylysinuria
- beta-aminoisobutyric acid, urinary excretion of
- cystinuria
- primary hyperoxaluria type 3
- hyperprolinemia type 2
- gastric cancer
- proteinuria, chronic benign
- primary hyperoxaluria type 2
