SLA2
Description
The SLA2 (Src like adaptor 2) is a protein-coding gene located on chromosome 20.
SLA2 is a human protein encoded by the SLA2 gene. It belongs to the SLAP family of adapter proteins and may play a crucial role in downregulating T and B cell-mediated responses. SLA2 inhibits antigen receptor-induced calcium mobilization and interacts with Cas-Br-M, a murine ecotropic retroviral transforming sequence. Two transcript variants encoding distinct isoforms have been identified for this gene. SLA2 has been shown to interact with CBL.
SLA2 acts as an adapter protein that negatively regulates T-cell receptor (TCR) signaling. It inhibits the activation of nuclear factor of activated T-cells (NFAT) by the TCR, potentially by linking signaling proteins like ZAP70 with CBL. This interaction leads to the CBL-dependent degradation of signaling proteins, ultimately downregulating TCR signaling.
SLA2 is also known as C20orf156, MARS, SLAP-2, SLAP2.
