SIRT2
Description
The SIRT2 (sirtuin 2) is a protein-coding gene located on chromosome 19.
SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase encoded by the SIRT2 gene in humans. Its functions are highly dependent on cellular context, with pleiotropic effects. SIRT2 is ubiquitously distributed, with high expression in the brain, particularly in the cortex, striatum, hippocampus, and spinal cord. SIRT2 is involved in various cellular processes, including regulation of microtubule acetylation, control of myelination in the nervous system, gluconeogenesis, and cell cycle control. Evidence suggests additional functions in the nucleus.
SIRT2 is a NAD-dependent protein deacetylase that removes acetyl groups from lysine residues on various proteins, including histones and alpha-tubulin. It also plays a role in protein demyristoylation and depalmitoylation, regulating the association of certain proteins with membranes. SIRT2 participates in a wide range of cellular processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. It acts as a tumor suppressor and plays a role in the regulation of blood glucose homeostasis and oxidative stress response. SIRT2 interacts with various proteins, including CDC20, FOXO3, FZR1, FOXO1, RELA, HOXA10, YWHAB, YWHAG, MAPK1/ERK2, MAPK3/ERK1, KMT5A, G6PD, cyclin E-CDK2, AURKA, CDK5R1, CDK5, HIF1A, EP300, SARS1, and BEX4.
SIRT2 is also known as SIR2, SIR2L, SIR2L2.
