SIN3B
Description
The SIN3B (SIN3 transcription regulator family member B) is a protein-coding gene located on chromosome 19.
SIN3B is a gene that encodes the Paired amphipathic helix protein Sin3b in humans. Sin3b interacts with various proteins including HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1. It acts as a transcriptional corepressor.
SIN3B acts as a transcriptional repressor, interacting with MXI1 to suppress MYC-responsive genes and counter MYC's oncogenic effects. It binds to MAD in MAD-MAX heterodimers, repressing transcription by tethering itself to DNA. SIN3B also forms a complex with FOXK1, repressing transcription and potentially regulating cell cycle progression by suppressing cell cycle inhibitor genes. As part of the SIN3B complex, it represses transcription and opposes the histone acetyltransferase activity of EP300. This is achieved through PHF12's recognition of H3K27ac marks and the activity of HDAC2. The SIN3B complex is recruited downstream of constitutively active gene transcriptional start sites via histone interactions, mitigating histone acetylation and RNA polymerase II progression within transcribed regions, thus contributing to transcription regulation.
SIN3B is also known as -.
