SIAH1
Description
The SIAH1 (siah E3 ubiquitin protein ligase 1) is a protein-coding gene located on chromosome 16.
SIAH1 is a human gene that encodes for an enzyme called E3 ubiquitin-protein ligase SIAH1. This enzyme is responsible for tagging proteins with ubiquitin, marking them for degradation by the proteasome. SIAH1 plays a role in a variety of cellular processes, including apoptosis (programmed cell death), the cellular response to low oxygen levels (hypoxia), and the regulation of gene expression. Several different versions of the SIAH1 protein can be made due to alternative splicing of the SIAH1 gene.
SIAH1 is an E3 ubiquitin-protein ligase that marks target proteins for degradation by the proteasome. It accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and directly transfers it to its substrates. This can happen through direct binding to substrates or by acting as part of larger E3 complexes. SIAH1 targets a wide range of proteins, including those involved in transcription regulation, cell signaling, and cell survival. Its activity is essential for many cellular processes such as apoptosis, tumor suppression, cell cycle regulation, axon guidance, and transcription regulation. SIAH1 interacts with various other proteins, including PEG3, GAPDH, AXIN1, and HIPK2, and is part of the Wnt signaling pathway.
SIAH1 is also known as BURHAS, SIAH1A.
