SHISA6
Description
The SHISA6 (shisa family member 6) is a protein-coding gene located on chromosome 17.
SHISA6 plays a crucial role in maintaining high-frequency synaptic transmission at the CA3-CA1 synapses in the hippocampus. It regulates the immobilization of AMPA-type glutamate receptors (AMPARs) at the postsynaptic density, ensuring the receptors remain active in the presence of glutamate and preventing synaptic depression. Furthermore, SHISA6 may contribute to the self-renewal and differentiation of spermatogonial stem cells by inhibiting the canonical Wnt signaling pathway.
SHISA6 is also known as -.
Associated Diseases
- refractive error
- 22q11.2 deletion syndrome
- reticular dysgenesis
- monocytopenia with susceptibility to infections
- neutropenia, severe congenital, 2, autosomal dominant
- hereditary neutrophilia
