SFN
Description
The SFN (stratifin) is a protein-coding gene located on chromosome 1.
SFN refers to the human gene SFN, which encodes the 14-3-3 protein sigma.
SFN, also known as 14-3-3 protein sigma, is an adapter protein involved in the regulation of a wide range of signaling pathways. It binds to a variety of partners, often through recognition of phosphorylated serine or threonine residues, and modulates the activity of its binding partners. For example, SFN inhibits the innate immune response by retaining GBP1 GTPase in the cytosol, acts as a p53-regulated inhibitor of cell cycle progression, and promotes epithelial cell growth by stimulating the Akt/mTOR pathway when bound to KRT17. SFN also regulates MDM2 autoubiquitination and degradation, leading to activation of p53.
SFN is also known as YWHAS.
Associated Diseases
- COVID-19
- urinary bladder cancer
- ringed hair disease
- hypotrichosis simplex
- isolated agammaglobulinemia
- breast cancer
- common variable immunodeficiency
- uncombable hair syndrome
