SF3B5
Description
The SF3B5 (splicing factor 3b subunit 5) is a protein-coding gene located on chromosome 6.
Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene.
SF3B5 is a component of the 17S U2 SnRNP complex, a large ribonucleoprotein complex involved in removing introns from transcribed pre-mRNAs. This complex plays a crucial role in early spliceosome assembly and recognizes the intron branch site during pre-mRNA splicing by selecting the branch-site adenosine, which is essential for the initial step of splicing. SF3B5 is part of the SF3B subcomplex within the 17S U2 SnRNP complex, which is necessary for the formation of the 'A' complex through the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. The binding of the SF3A and SF3B subcomplexes upstream of the branch site, independent of the sequence, is critical for anchoring U2 snRNP to the pre-mRNA. Additionally, SF3B5 is a component of the minor spliceosome, which handles the splicing of U12-type introns in pre-mRNAs.
SF3B5 is also known as SF3b10, Ysf3.
