SF3A2
Description
The SF3A2 (splicing factor 3a subunit 2) is a protein-coding gene located on chromosome 19.
SF3A2 is a protein encoded by the SF3A2 gene in humans. It is a subunit of the splicing factor 3a protein complex, which is necessary for the conversion of 15S U2 snRNP into an active 17S particle involved in pre-mRNA splicing. The protein interacts with subunit 1 of the complex through its amino-terminus, and its single zinc finger domain binds to the 15S U2 snRNP. SF3A2 may also function independently of its RNA splicing role as a microtubule-binding protein. SF3A2 interacts with DDX46.
SF3A2 is a component of the 17S U2 SnRNP complex, a large ribonucleoprotein complex involved in removing introns from transcribed pre-mRNAs. This complex plays a critical role in early spliceosome assembly and recognizes the intron branch site during pre-mRNA splicing, promoting the selection of the pre-mRNA branch-site adenosine. SF3A2 is part of the SF3A subcomplex within the 17S U2 SnRNP complex, contributing to the assembly of the 17S U2 snRNP and subsequent formation of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. SF3A2 also participates in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex, and interacts directly with the duplex formed by U2 snRNA and the intron.
SF3A2 is also known as PRP11, PRPF11, SAP62, SF3a66.
