SETD7
Description
The SETD7 (SET domain containing 7, histone lysine methyltransferase) is a protein-coding gene located on chromosome 4.
Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene.
SETD7 is a histone methyltransferase that specifically adds a single methyl group to lysine 4 of histone H3 (H3K4me1). This modification is a key marker for epigenetic transcriptional activation. SETD7 plays a central role in activating the transcription of genes such as collagenase and insulin. It is recruited to the insulin promoter by IPF1/PDX-1, leading to increased transcription. SETD7 also has methyltransferase activity towards non-histone proteins, including CGAS, p53/TP53, TAF10, and possibly TAF7. It recognizes and binds to a specific sequence within these proteins, [KR]-[STA]-K. SETD7 monomethylates lysine 189 of TAF10, increasing its affinity for RNA polymerase II. It also monomethylates lysine 372 of p53/TP53, stabilizing the protein and enhancing p53/TP53-mediated transcriptional activation. SETD7 monomethylates lysine 491 of CGAS, promoting interaction between SGF29 and CGAS. SETD7 interacts with IPF1/PDX-1.
SETD7 is also known as KMT7, SET7, SET7/9, SET9.
