SERTAD1
Description
The SERTAD1 (SERTA domain containing 1) is a protein-coding gene located on chromosome 19.
SERTAD1 is a protein encoded by the SERTAD1 gene in humans. It has been shown to interact with CREB-binding protein, Cyclin-dependent kinase 4, and P16.
SERTAD1 acts as a coregulator at E2F-responsive promoters, integrating signals from PHD- and/or bromodomain-containing transcription factors. It stimulates the transcriptional activity of E2F1/TFDP1 and makes the activity of cyclin D1/CDK4 resistant to inhibition by CDKN2A/p16INK4A.
SERTAD1 is also known as SEI1, TRIP-Br1, TRIPBR1.
Associated Diseases
- cancer
- hyperinsulinemic hypoglycemia, familial, 2
- exercise-induced hyperinsulinism
- GCGR-related hyperglucagonemia
- renal cysts and diabetes syndrome
- islet cell adenomatosis
- hyperinsulinemic hypoglycemia, familial, 1
- pancreatic agenesis 2
- hyperinsulinism-hyperammonemia syndrome
- hereditary chronic pancreatitis
