SERPINB10
The SERPINB10 Gene: A Key Player in Inflammation and Disease
Description
The SERPINB10 gene, located on chromosome 18q21, encodes a protein called serpin family B member 10 (serpinB10). SerpinB10 belongs to the serpin superfamily of proteins, known for their role in regulating various biological processes, especially inflammation.
SerpinB10 is primarily expressed in liver cells and plays a crucial role in the body‘s innate immune response. It acts as a potent inhibitor of serine proteases, enzymes involved in inflammation and blood coagulation. By inhibiting these proteases, serpinB10 helps to control and resolve inflammatory reactions.
Associated Diseases
Defects in the SERPINB10 gene have been linked to several diseases, including:
- Dermatitis herpetiformis (DH): A chronic, autoimmune skin condition characterized by intense itching and blistering.
- Celiac disease: An autoimmune disorder that causes damage to the small intestine after eating gluten.
- Autoimmune hepatitis: A chronic inflammation of the liver caused by the body‘s immune system attacking its own liver cells.
- Sjogren‘s syndrome: An autoimmune disorder that affects the exocrine glands, leading to dryness of the eyes, mouth, and other tissues.
Did you Know ?
Mutations in the SERPINB10 gene are found in approximately 95% of individuals with dermatitis herpetiformis, highlighting the significant role of this gene in the development of this condition.
