SERPINA12

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Description

The SERPINA12 (serpin family A member 12) is a protein-coding gene located on chromosome 14.

SERPINA12, also known as OL-64, is an adipokine that regulates insulin action by specifically blocking the activity of the protease KLK7 in white adipose tissues. This function has been observed in various studies (PubMed:16030142, PubMed:23370777, PubMed:26199422, PubMed:28668641).

SERPINA12 is also known as OL-64.

Associated Diseases

• Hereditary palmoplantar keratoderma, Gamborg-Nielsen type