SENP8
Description
The SENP8 (SUMO peptidase family member, NEDD8 specific) is a protein-coding gene located on chromosome 15.
SENP8 (Sentrin-specific protease 8) is an enzyme encoded by the SENP8 gene in humans. NEDD8 (Neural precursor cell expressed developmentally downregulated 8) is a ubiquitin-like protein that attaches to the cullin subunit of several ubiquitin ligases, a process called neddylation. Neddylation is essential for optimal ubiquitin ligase activity.
SENP8 is a protease that plays a critical role in the NEDD8 pathway by performing two essential functions: processing full-length NEDD8 into its mature form and removing NEDD8 from targeted proteins like cullins or p53. These functions are essential for regulating the activity of ubiquitin ligases.
SENP8 is also known as DEN1, NEDP1, PRSC2.
Associated Diseases
- ovarian cancer
- retinitis pigmentosa
- X-linked retinal dysplasia
- severe early-childhood-onset retinal dystrophy
- reticular dystrophy of the retinal pigment epithelium
- choroidal dystrophy, central areolar, 1
- age related macular degeneration 4
- age related macular degeneration 7
- age related macular degeneration 11
