SENP6
Description
The SENP6 (SUMO specific peptidase 6) is a protein-coding gene located on chromosome 6.
Sentrin-specific protease 6 (SENP6) is an enzyme encoded by the SENP6 gene in humans. Ubiquitin-like molecules (UBLs), such as SUMO1, are similar in structure to ubiquitin and can be attached to target proteins in a similar way. However, unlike ubiquitin, UBL attachment does not lead to protein degradation. SUMO1 modification is involved in targeting RANGAP1 to the nuclear pore complex and stabilizing I-kappa-B-alpha (NFKBIA) from degradation by the 26S proteasome. Similar to ubiquitin, UBLs are synthesized as precursor proteins with one or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein.
SENP6 is a protease that removes SUMO1, SUMO2, and SUMO3 from proteins. It prefers to process poly-SUMO2 and poly-SUMO3 chains, but does not efficiently remove SUMO1, SUMO2, or SUMO3 precursors. SENP6 removes SUMO1 from RXRA, leading to transcriptional activation. It plays a role in chromosome alignment and spindle assembly by regulating the kinetochore CENPH-CENPI-CENPK complex. SENP6 removes SUMO from PML and CENPI, preventing their degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. SENP6 also removes SUMO from RPA1, preventing the recruitment of RAD51 to DNA damage sites and inhibiting DNA repair through homologous recombination.
SENP6 is also known as SSP1, SUSP1.
