SEC62
Description
The SEC62 (SEC62 homolog, preprotein translocation factor) is a protein-coding gene located on chromosome 3.
SEC62 is a protein that is involved in the transport of proteins across the endoplasmic reticulum (ER) membrane. It is part of the Sec61 complex, which is essential for protein translocation. SEC62, along with SEC63, is associated with the ribosome-free Sec61 complex. It is thought that the Sec61-Sec62-Sec63 complex may be involved in post-translational protein translocation into the ER. Additionally, this complex may also play a role in the backward transport of ER proteins that are destined for degradation by the ubiquitin-proteasome pathway.
SEC62 facilitates the post-translational movement of precursor polypeptides across the endoplasmic reticulum (ER). It is hypothesized to function as a targeting receptor for small presecretory proteins characterized by short and nonpolar signal peptides. SEC62 accurately positions newly synthesized presecretory proteins within the SEC61 channel-forming translocon complex, initiating channel opening and allowing polypeptide translocation into the ER lumen. This information is derived from scientific research documented in PubMed IDs 22375059 and 29719251.
SEC62 is also known as Dtrp1, HTP1, TLOC1, TP-1.
Associated Diseases
- Griscelli syndrome type 3
- uncombable hair syndrome
- oculocutaneous albinism type 3
- microcephaly-albinism-digital anomalies syndrome
- Miyoshi myopathy
- Tietz syndrome
- acquired factor X deficiency
- ermine phenotype
- hypotrichosis simplex
- cancer
- Waardenburg syndrome, IIa 2F
