SEC16B
Description
The SEC16B (SEC16 homolog B, endoplasmic reticulum export factor) is a protein-coding gene located on chromosome 1.
SEC16B, also known as Leucine zipper transcription regulator 2, Regucalcin gene promoter region-related protein p117, and SEC16 homolog B, is a protein encoded by the SEC16B gene in humans. Originally discovered as a transcription factor that binds to a specific motif in the regucalcin gene, it was later found to be an endoplasmic reticulum export factor. The SEC16B gene spans 4.1 kbp and is located on chromosome 1q25.2. Its expression is stimulated by various signaling factors in cells. SEC16B is found in various cellular compartments, including the plasma membrane, cytoplasm, mitochondria, microsomes, and nucleus. Cytoplasmic SEC16B can translocate to the nucleus. When phosphorylated, SEC16B binds to a specific motif in the promoter region of various genes, enhancing their expression and playing a crucial role in gene regulation. SEC16B also exhibits protective effects against apoptotic cell death induced by different signaling factors.
SEC16B plays a crucial role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). It is essential for the movement of secretory cargo from the endoplasmic reticulum to the Golgi apparatus. Furthermore, SEC16B is involved in peroxisome biogenesis, regulating the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the endoplasmic reticulum to peroxisomes.
SEC16B is also known as LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16S.
