SDPR
The SDPR Gene: A Comprehensive Guide to Its Role in Health and Disease
Description
The SDPR gene, located on chromosome 17q25.3, encodes the serotonin dopamine reuptake transporter (SDPRT). SDPRT is a protein that plays a crucial role in regulating the levels of neurotransmitters serotonin and dopamine in the brain. Serotonin and dopamine are involved in a wide range of brain functions, including mood, behavior, and motivation.
Associated Diseases
Mutations in the SDPR gene have been linked to several psychiatric and neurological disorders, including:
- Schizophrenia
- Bipolar disorder
- Depression
- Anxiety disorders
- Parkinson's disease
- Attention deficit hyperactivity disorder (ADHD)
Dysregulation of serotonin and dopamine levels, caused by SDPR gene defects, can lead to imbalances in neurotransmitter signaling, which can result in the symptoms associated with these disorders.
Did you Know ?
According to a study published in the journal "Nature Genetics," approximately 1 in 100 people carry a common genetic variant in the SDPR gene that has been associated with an increased risk for schizophrenia.
