SDK2
Description
The SDK2 (sidekick cell adhesion molecule 2) is a protein-coding gene located on chromosome 17.
SDK2 is a protein that belongs to the immunoglobulin superfamily, characterized by the presence of immunoglobulin domains. It contains two immunoglobulin domains and thirteen fibronectin type III domains, which are involved in various cellular functions, including binding to DNA, heparin, and cell surfaces. Although SDK2 shares similarities with the Drosophila sidekick gene product, its specific function remains unknown. Evidence suggests the existence of alternative splicing at the SDK2 gene locus, but the complete nature of additional variants is yet to be determined.
SDK2 is an adhesion molecule essential for the formation of specific synaptic connections in the retina, particularly those involved in motion detection. It promotes synapse formation between retinal ganglion cells W3B-RGCs and excitatory amacrine cells VG3-ACs, playing a crucial role in motion detection. This function is achieved through homophilic interactions, where SDK2 molecules on adjacent cells bind to each other, facilitating cell adhesion and synapse formation.
SDK2 is also known as -.
