SDE2
Description
The SDE2 (SDE2 telomere maintenance homolog) is a protein-coding gene located on chromosome 1.
SDE2 plays a critical role in mitigating DNA damage caused by ultraviolet light. It prevents the monoubiquitination of PCNA, a key protein involved in DNA replication, thereby inhibiting translesion DNA synthesis. This inhibition helps to counteract the damaging effects of replication stress. Following binding to PCNA, SDE2 undergoes cleavage and complete degradation, which is essential for the progression of the S-phase of the cell cycle after DNA damage.
SDE2 is also known as C1orf55, dJ671D7.1.
