SDC4
Description
The SDC4 (syndecan 4) is a protein-coding gene located on chromosome 20.
Syndecan-4 is a protein encoded by the SDC4 gene in humans. It's one of four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are prominent plasma membrane proteoglycans, with their intracellular domain interacting with the actin cytoskeleton and signaling molecules. They're commonly found on the surface of fibroblasts and epithelial cells. Syndecans bind to fibronectin on the cell surface and connect to cytoskeletal and signaling proteins inside the cell to regulate integrin function in cell-matrix adhesion. They also bind to FGFs and transport them to the FGF receptor on the same cell. As a co-receptor or regulator, mutations in certain proteoglycans can cause developmental defects due to disrupted distribution or inactivation of signaling molecules. Syndecans share similar structural features, including heparan sulfate chains for interaction with factors like matrix molecules, growth factors, and enzymes, a chondroitin sulfate chain, a transmembrane domain for self-association, a C1 domain for actin-association with the cytoskeleton, a variable domain unique to each syndecan, a C2 domain for attaching to PDZ proteins, and a tendency to form homodimers or multimers.
Syndecan-4 (SDC4) is a cell surface proteoglycan that regulates exosome biogenesis in collaboration with SDCBP and PDCD6IP.
SDC4 is also known as SYND4.
