SCRIB

Description

The SCRIB (scribble planar cell polarity protein) is a protein-coding gene located on chromosome 8.

SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein encoded by the SCRIB gene in humans. It was initially identified in Drosophila melanogaster as a tumor suppressor protein, functioning in a complex with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae). In humans, SCRIB is a membrane protein involved in cell migration, cell polarity, and cell proliferation in epithelial cells. Its strong homology to the Drosophila protein suggests a potential role in cancer progression. SCRIB is crucial for synaptic function, neuroblast differentiation, and epithelial polarization in Drosophila melanogaster. In humans, it acts as a scaffold protein involved in cellular differentiation, specifically regulating epithelial and neuronal morphogenesis. Deficiencies in SCRIB impair cell polarity and movement. SCRIB is also likely involved in establishing apical-basal polarity and the transition from the G1 phase to the S phase in the cell cycle, linking it to cell proliferation and exocytosis. The SCRIB gene's protein products, along with DLGAP5 and LLGL1, form the Scribble complex, located in the basolateral membrane. This complex plays a critical role in determining cell polarity and proliferation in epithelial cells.

The SCRIB gene can be translated into two proteins: oSCRIB and SCRIB. oSCRIB acts as a repressor of SCRIB translation, potentially by interfering with the ribosome's ability to initiate translation at the SCRIB start codon. However, this repression is not complete, likely due to leaky scanning, which allows some ribosomes to bypass the oSCRIB start codon and initiate translation at the SCRIB start codon.

SCRIB is also known as CRIB1, SCRB1, SCRIB1, Vartul, oSCRIB.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing