SCG3
Description
The SCG3 (secretogranin III) is a protein-coding gene located on chromosome 15.
Secretogranin III, also known as SCG3, is a protein encoded by the SCG3 gene in humans. It belongs to the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may act as precursors for biologically active peptides. While some granins have been shown to aid in sorting and processing prohormones, the specific function of SCG3 remains unknown.
SCG3 is involved in the regulation of secretory granule biogenesis (PubMed:19357184). It acts as a sorting receptor for intragranular proteins, including chromogranin A/CHGA (By similarity). SCG3 may also play a role in angiogenesis, promoting endothelial proliferation, migration, and tube formation through the MEK/ERK signaling pathway (PubMed:29154827). {ECO:0000250|UniProtKB:P47868, ECO:0000269|PubMed:19357184, ECO:0000269|PubMed:29154827}
SCG3 is also known as SGIII.
Associated Diseases
- developmental and epileptic encephalopathy
- undetermined early-onset epileptic encephalopathy
- schizophrenia
- schizophrenia 15
- Duane retraction syndrome
- Phelan-McDermid syndrome
