SCARNA2
Description
The SCARNA2 (small Cajal body-specific RNA 2) is a ncRNA gene located on chromosome 1.
SCARNA2 is a small nucleolar RNA (snoRNA) that is found in Cajal bodies, which are nuclear substructures involved in the processing and assembly of snRNPs and other ribonucleoprotein complexes. It is involved in the biogenesis of ribosomal RNA (rRNA) and is thought to guide the modification of rRNA by methylation.
SCARNA2 (Small Cajal body-specific RNA 2) is a small nucleolar RNA (snoRNA) that is involved in the biogenesis of ribosomal RNA (rRNA). It is localized to Cajal bodies, which are nuclear substructures involved in the processing and assembly of snRNPs and other ribonucleoprotein complexes. SCARNA2 is thought to guide the modification of rRNA by methylation, a process that is essential for the proper folding and function of rRNA. This methylation event is crucial for the assembly of ribosomes, which are essential for protein synthesis. Specifically, SCARNA2 is responsible for guiding the methylation of the 2'-hydroxyl group of adenosine residues in rRNA. This modification is known to be crucial for the stability and function of rRNA. Mutations in SCARNA2 have been linked to human disease, suggesting its essential role in human health.
SCARNA2 is also known as HBII-382, mgU2-25/61.
