SARNP


Description

The SARNP (SAP domain containing ribonucleoprotein) is a protein-coding gene located on chromosome 12.

SAP domain-containing ribonucleoprotein is a protein that in humans is encoded by the SARNP gene.

SARNP binds to both single-stranded and double-stranded DNA, with a stronger preference for single-stranded DNA. It specifically binds to scaffold/matrix attachment region DNA and also interacts with single-stranded RNA. SARNP enhances the RNA unwinding activity of DDX39A, suggesting a role in RNA processing. It is thought to participate in the regulation of cell growth, metabolism, and potentially carcinogenesis. SARNP is a component of the TREX complex, which connects mRNA transcription, processing, and nuclear export. It specifically associates with spliced mRNA, not unspliced pre-mRNA. TREX is recruited to spliced mRNAs independently of transcription, binds upstream of the exon-junction complex (EJC), and is recruited to the 5' end of mRNA in a splicing- and cap-dependent manner. TREX functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and the production of infectious virus.

SARNP is also known as CIP29, HCC1, HSPC316, THO1.

Associated Diseases



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