SAFB2
Description
The SAFB2 (scaffold attachment factor B2) is a protein-coding gene located on chromosome 19.
SAFB2 is a protein encoded by the SAFB2 gene in humans.
SAFB2 binds to scaffold/matrix attachment region (S/MAR) DNA. It can act as an estrogen receptor corepressor and also inhibits cell proliferation.
SAFB2 is also known as -.
Associated Diseases
- prostate cancer
- X-linked intellectual disability-macrocephaly-macroorchidism syndrome
- familial male-limited precocious puberty
- isolated congenital hypogonadotropic hypogonadism
- spastic paraplegia-precocious puberty syndrome
- 46,XX testicular disorder of sex development
- spermatogenic failures 50
- partial chromosome Y deletion
- 46,XY complete gonadal dysgenesis
- spermatogenic failure 25
- intellectual disability, X-linked syndromic, Turner type
