RYBP
Description
The RYBP (RING1 and YY1 binding protein) is a protein-coding gene located on chromosome 3.
RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.
RYBP is a component of Polycomb group (PcG) multiprotein PRC1-like complexes, which are essential for maintaining the transcriptionally repressive state of numerous genes, including Hox genes, throughout development. These complexes remodel chromatin and modify histones, specifically monoubiquitinating histone H2A 'Lys-119', leading to heritable changes in gene expression. RYBP plays a role in silencing one copy of the X chromosome in XX females by mediating monoubiquitination of histone H2A 'Lys-119' on the X chromosome. Additionally, RYBP may stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. It inhibits ubiquitination and subsequent degradation of TP53, thereby regulating transcription of TP53 target genes. Furthermore, RYBP may regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1, impacting apoptosis. RYBP might also act as a repressor of the transcriptional activity of E4TF1 and potentially bind to DNA. It has been implicated in suppressing tumor growth and metastasis in breast cancer by downregulating SRRM3.
RYBP is also known as AAP1, APAP-1, DEDAF, YEAF1.
