RXRG
Description
The RXRG (retinoid X receptor gamma) is a protein-coding gene located on chromosome 1.
Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor involved in mediating the antiproliferative effects of retinoic acid (RA). It forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, enhancing DNA binding and transcriptional function on their respective response elements. This gene is expressed at lower levels in non-small cell lung cancer cells. Different isoforms are produced through alternative splicing. RXR-gamma has been shown to interact with ITGB3BP.
RXR-gamma, also known as NR2B3, is a nuclear receptor that binds to retinoic acid response elements (RAREs) as heterodimers with retinoic acid receptors (RARs). This binding is triggered by the presence of ligands, either all-trans or 9-cis retinoic acid. The specific RAREs targeted by these heterodimers consist of tandem 5'-AGGTCA-3' sites, known as DR1-DR5. RXRs have a high affinity for 9-cis retinoic acid.
RXRG is also known as NR2B3, RXR-gamma, RXRC, RXRgamma.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- T-cell non-Hodgkin lymphoma
- schizophrenia
