RXRB
Description
The RXRB (retinoid X receptor beta) is a protein-coding gene located on chromosome 6.
Retinoid X receptor beta (RXRB), also known as NR2B2, is a nuclear receptor encoded by the RXRB gene. It plays a role in mediating the effects of retinoic acid (RA), a crucial molecule for development and cell growth. RXRB forms heterodimers with other nuclear receptors, including retinoic acid receptors (RARs), thyroid hormone receptors, and vitamin D receptors. These heterodimers increase DNA binding and transcriptional function on their respective response elements. The RXRB gene is located within the major histocompatibility complex (MHC) class II region on chromosome 6.
RXRB, a receptor for retinoic acid, forms heterodimers with other retinoic acid receptors (RARs) to regulate gene expression. This heterodimer, RAR/RXR, binds to specific DNA sequences called retinoic acid response elements (RAREs) in response to its ligands, all-trans or 9-cis retinoic acid. This binding leads to the activation or repression of target genes, influencing various biological processes.
RXRB is also known as DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta.
