RTN4RL2
Description
The RTN4RL2 (reticulon 4 receptor like 2) is a protein-coding gene located on chromosome 11.
RTN4RL2 is a cell surface receptor involved in inhibiting neurite outgrowth, likely mediated by MAG. It plays a crucial role in postnatal brain development, contributing to axon migration across the midline and the formation of the corpus callosum. While it may not significantly influence axon regeneration in adults, it protects motoneurons from apoptosis, likely through MAG. Similar to its family members, it restricts dendritic spine and synapse formation during brain development. RTN4RL2 signaling activates Rho, leading to actin cytoskeleton reorganization.
RTN4RL2 is also known as NGRH1, NgR2.
Associated Diseases
- congenital dyserythropoietic anemia type 4
- hemoglobin D disease
- hepatorenocardiac degenerative fibrosis
- Wolfram syndrome
- porencephaly-microcephaly-bilateral congenital cataract syndrome
- dominant beta-thalassemia
- cancer
