RTN3
Description
The RTN3 (reticulon 3) is a protein-coding gene located on chromosome 11.
RTN3 is a human protein encoded by the RTN3 gene. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues.
RTN3 plays a role in membrane trafficking during the early stages of protein secretion. It inhibits the activity of BACE1, an enzyme involved in the processing of amyloid precursor protein, potentially reducing amyloid-beta production. RTN3 can trigger the caspase-8 cascade, leading to apoptosis (programmed cell death). Under endoplasmic reticulum stress, it may promote the movement of BCL2, an anti-apoptotic protein, to the mitochondria. RTN3 induces the formation of endoplasmic reticulum tubules, which are involved in protein transport and lipid metabolism. Additionally, RTN3 acts as a regulator of inflammation by interacting with TRIM25 and RIGI, inhibiting RIGI ubiquitination and consequently suppressing the activation of IRF3 and NF-kappa-B, key players in the inflammatory response.
RTN3 is also known as ASYIP, HAP, NSPL2, NSPLII, RTN3-A1.
