RTKN
Description
The RTKN (rhotekin) is a protein-coding gene located on chromosome 2.
Rhotekin is a scaffold protein encoded by the RTKN gene in humans. It interacts with GTP-bound Rho proteins, inhibiting their GTPase activity. This may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth, and transformation. Dysregulation of the Rho signaling pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Rhotekin mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. It may also play a novel role in the organization of septin structures.
RTKN is also known as RTKN-1.
