RTCB
Description
The RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase) is a protein-coding gene located on chromosome 22.
RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase) is a human protein encoded by the RTCB gene. It is located in the stress granule of cells. Although no crystal structure of human RTCB is known, homology models based on other RtcB-family ligases are available. The structure of Pyrococcus horikoshii RtcB, which utilizes GTP instead of ATP, reveals two manganese (Mn2+) cofactors and a mechanism involving a covalently linked GTP-histidine-RtcB intermediate. The corresponding residue in human RTCB, H428, is conserved. RTCB belongs to the RtcB family of ATP-dependent RNA ligases, named after the E. coli RtcB protein. Bacterial RtcB acts as a tRNA ligase, rejoining broken stem-loops in case of damage, and also catalyzes RNA splicing. The eukaryotic homologs of RtcB, including human RTCB, participate in the tRNA-splicing ligase complex.
RTCB is also known as C22orf28, DJ149A16.6, FAAP, HSPC117.
Associated Diseases
- lysosomal storage disease
- cancer
- breast cancer
- pancreatic ductal adenocarcinoma
- osteoporosis-pseudoglioma syndrome
- bipolar disorder
- myeloid leukemia
