RRAGD
Description
The RRAGD (Ras related GTP binding D) is a protein-coding gene located on chromosome 6.
RRAGD, also known as RagD, is a guanine nucleotide-binding protein that plays a critical role in cellular response to amino acid availability by regulating the mTORC1 signaling pathway. It forms heterodimeric complexes with either RagA/RRAGA or RagB/RRAGB and alternates between inactive (GTP-bound) and active (GDP-bound) forms. The active form of RRAGD, which is GDP-bound and complexed with GTP-bound RagA/RRAGA or RagB/RRAGB, promotes the recruitment of mTORC1 to lysosomes and its subsequent activation by the GTPase RHEB. This process is essential for the activation of the MTOR signaling cascade by amino acids. Additionally, RRAGD is a central component of the non-canonical mTORC1 complex, which operates independently of RHEB and specifically facilitates the phosphorylation of MiT/TFE factors TFEB and TFE3. The GDP-bound form of RRAGD mediates the recruitment of TFEB and TFE3.
RRAGD is also known as HOMG7, RAGD, bA11D8.2.1.
