RRAGC
Description
The RRAGC (Ras related GTP binding C) is a protein-coding gene located on chromosome 1.
RRAGC, also known as Ras-related GTP binding C, is a protein encoded by the RRAGC gene in humans. It is a monomeric guanine nucleotide-binding protein (G protein), which acts as a molecular switch in various cellular processes and signaling pathways by binding GTP or GDP.
RRAGC is a guanine nucleotide-binding protein that plays a crucial role in cellular responses to amino acid availability. It regulates the mTORC1 signaling cascade, a key pathway in cell growth and metabolism. RRAGC forms heterodimers with RRAGA or RRAGB and exists in two forms: inactive (GTP-bound) and active (GDP-bound). The active form recruits mTORC1 to the lysosomes, where it is activated by the GTPase RHEB. This activation of mTORC1 by amino acids is essential for cell growth and metabolism. RRAGC also participates in the non-canonical mTORC1 complex, which operates independently of RHEB and directly phosphorylates MiT/TFE factors TFEB and TFE3. The GDP-bound form of RRAGC facilitates the recruitment of these factors.
RRAGC is also known as GTR2, LNGODS, LNGOS, RAGC, TIB929.
